研究業績

佐藤 公彦 (SATO KIMIHIKO) 教授

専門分野

有機化学
生化学
化学発がん
生命科学

略歴

東北大学理学部化学科卒業
東北大学大学院理学研究科修士課程終了
東京大学理系大学院博士課程修了
弘前大学医学部生化学第二講座助手
弘前大学医学部生化学第二講座助教授
弘前大学大学院保健学研究科教授
弘前大学名誉教授
秋田看護福祉大学教授

最終学位

理学博士(東京大学大学院)

所属学会

日本癌学会
日本分子腫瘍マーカー研究会(特別会員)
アメリカ癌学会

研究課題

がん細胞の発生機構の解明に関する研究

社会活動

大館国際情報学院中学校高校評議会委員

主な研究実績

区分 著書・学術論文等の題名 単著/
共著
発行所・発表雑誌等又は
発表学会名
発行又は発表年月
論文 Nonclonal growth of preneoplastic cells positive for glutathione S-transferase P-form in the rat liver. 共著

Cancer Sci., 103(8), 1445-1450.

2012年

論文 Bile duct-bound growth of precursor cells of preneoplastic foci inducible in the initiation stage of rat chemical hepatocarcinogenesis by 2-acetylamino- fluorene. 共著

Jpn J. Clin. Oncol., 38, 604-610.

2008年

論文 Altered gene expression of transcriptional regulatory factors in tumor marker-positive cells during chemically induced hepatocarcinogenesis. 共著

Toxicol Lett., 167(2), 106-13.

2006年

論文 Enzymatic detection of precursor cell populations of preneoplastic foci positive for (-glutamyltranspeptidase in rat liver. 共著

Int. J. Cancer , 115(5), 711-716.

2005年

論文 Kinetic-controlled Hydrolysis of Leu-Val-Val-hemorphin-7 Catalyzed by Angiotensin-converting Enzyme from Rat Brain 共著

Peptides, 24(7), 1075-1082.

2003年

論文 Anomalous elevation of glutathione S-transferase P-form (GST-P) in the elementary process of epigenetic initiation of chemical hepatocarcinogene is in rats. 共著

Carcinogenesis, 23(7), 457- 462.

2002年

論文 Activation of mouse Pi-class gluta-thione S-transferase gene by Nrf2(NF-E2-related factor 2) and androgen. 共著

Biochem. J., 364(Pt 2), 563-570.

2002年

論文 Nrf2 transactivator-independent GSTP1-1 expression in “GSTP1-1 positive” single cells inducible in female mouse liver by DEN: a preneoplastic character of possible initiated cells 共著

Carcinogenesis, 23(3), 457-462.

2002年

論文 Lipid peroxidation end products-responded induction of a preneoplastic marker enzyme glutathione S-transferase P-form (GST-P) in rat liver on admistration via the portal vein. 共著

Mutation Res., 483(1-2), 65-72.

2001年

論文 Increase intake water for prevention of cancer: an enzymological lesson? 単著

Asian Pacific J Cancer Prevention, 2, 75-80.

2001年

論文 Oxidative stress promotes the development of transformation: involvement of a potent mutagenic lipid peroxidation product, acrolein. 共著

Carcinogenesis, 22(6), 935-941.

2001年

論文 Cyclopentenone prostaglandins as potential inducers of phase II detoxification enzymes, 15-deoxy-delta(12,14)-prostaglandin J2-induced expression of glutathione S-transferases 共著

J. Biol. Chem., 275, 11291-11299.

2000年

論文 A One-Hour ELISA for Quantitation of Acrolein and Hydroxynonenal-Modified proteins by Epitope-Bound Casein Method. 共著

Anal Biochem., 270(2), 323-328.

1999年

論文 Quantitative differences in the active site hydrophobicity of five huma glutathione S-transferase isoenzymes: Water-soluble carcinogen selective properties of the neoplastic GSTP1-1 species. 共著

Arch.Biochem. Biophys., 361, 271-276.

1999年

論文 Weak electrophile selective characteristics of the rat preneoplastic marker Enzyme glutathione S-transferase P-form, GST-P(7-7): A theory of linear free energy relationships for evaluation of the active site hydrophobicity of isoenzymes. 単著

Garcinogenesis, 19(9), 1665-1671.

1998年

論文 Over-expression of glutathione S-transferase Yp isozyme and concomitantdown-regulation of Ya isozyme in renal Cell carcinoma of rats induced by ferric nitrilotriacetate 共著

Carcinogenesis, 19(5), 897-903.

1998年

論文 An Nrf2/Small Maf heterodimer mediates the induction of PhaseⅡ detoxifying enzyme genes through antioxidant response elements 共著

Biochem.Biophys.Res.Commun., 236, 313-322.

1997年

論文 Epitope mapping of a monoclonal antibodyto human glutathione transferase P1-1 the binding of which is inhibited by glutathione 共著

Biochem.J., 321, 531-536.

1997年

論文 Lentinan enhance sensitivity of mouse colon 26 tumor to and decreases glutathione transferase expression 共著

J pn.J.Cancer Res., 87, 1171-1178.

1997年

論文 Oxidative stress response in iron-Induced renal carcinogenesis: Acute nephrotoxicity mediates the enhanced expression of glutathione S-transferase Yp isozyme 共著

Arch.Biochem.Biophys., 329, 39-46.

1996年

論文 The high non-enzymatic conjugation rates of some glutathione S-transferase(GST) substrates at high glutathione concentrations 共著

Carcinogenesis, 16, 869-874.

1995年

論文 Effect of fish oil on the development of AOP-induced glutathione S-transferase placental form positive hipatocellular foci in make F344 rats 共著

Nutrition and Cancer, 24, 187-195.

1995年

論文 Decreased exp ression of glutathione S-transferases and increased fatty change in peroxisomal enzye-negative foci induced by clofibrate in rat livers 共著

Carcinogenesis, 16, 1609-1704.

1995年

論文 Lack of correlated expression between the glutathione S- transferase P-form and the oncogene products, c-Jun and c-Fos, in rat tissues and preneoplastic hepatic foci 共著

Carcinogenesis, 16, 567-571.

1995年

論文 c-Jun expression in single cells and preneoplastic foci induced by diethylnitrosamine in B6C3F1 mice:comparison with the expression of pi-class glutathione S-transferase 共著

Carcinogenesis, 15, 1853-1857.

1994年

論文 Loss of peroxisomal enzyme espression in preneoplastic and neoplastic lesios induced by poroxisome proliferators in rat livers 共著

Carcinogenesis, 13, 265-269.

1992年

論文 Specific expression of glutathione S-transferase Pi forms in preneoplastic tissues: Their properties and functions 共著

Thoku J.Exp.Med., 168, 97-103.

1992年

論文 Modulation of class Pi glutathione Transferase activity by sulfhydryl Group modification 共著

Arch.Viochem. Viophys., 268, 178-182.

1991年

論文 Biochemical characteristics of a preneoplastic marker enzyme glutathione S-transferase P- form(7-7) 共著

Arch.Biochem.Biophys., 285, 312-316.

1991年

論文 Age-related alterations of enzyme activities and subunits of gepatic glutathione S-transferases in make and femate Fischer-344 rats 共著

Biochem. Bio Phys Acta, 1077, 325-331.

1991年

論文 Induction of glutathione S-transferase P-form in primary cultured rat liver Parenchymal cells by co-planar Polychlorinated biphenyl congeners 共著

Biochem.J., 281, 539-543.

1991年

論文 A new class of rat glutathione S-transferase Yrs-Yrs inactivating reactive sulfate esters as metabokites of acrcinogenic arylmethanol 共著

J.Biol.Chem., 265, 11973-11981.

1990年

論文 A cDNA sequence a class pi glutathione S-transferase of mouse 共著

Nucleic Acids Res., 18, 4606.

1990年

論文 Role of cysteine residues in the Activity of rat glutathione transferase P(7-7) 共著

Biochem. Biophys Res Commun, 1077, 325-331.

1990年

論文 Comparison of enzyme phonetypes in human Bladder tumors and experimentally induced hyperplastic and neoplastic lesions of the rat urinary bladder 共著

Virchows Arch. V. Cell Pathol., 56, 307-316.

1989年

論文 Transient induction of single GST-P positive hepatocytes by DEN 共著

Carcinogene sis, 10, 2107-2111.

1989年

論文 Stable phenotypic expression of glutathione S-transferase placental form and unstable phenotypic expression of γ-glutamyltransferase in rat liver preneoplastic and neoplastic lesions 共著

Carcinogene sis, 9, 215-220.

1988年

論文 The subunit structure of a major glutathione S-transferase form, Mt,in rat testis 共著

Eur.J.Bio chem., 176, 551-557.

1988年

論文 Single GST-P positive liver cells—putative initiated hipatocytes 共著

Carcinogene sis, 8, 483-486.

1987年

論文 Purification of a new acidic glutathione S-transrerase,GST-Yn1Yn1,with a high leukotriene- C4 synthase activity from rat brain transferase isozymes 共著

Eur.J.Bio chem., 170, 159-164.

1987年

論文 Immunohistochemically demonstrated increase in glutathione S-transferase species in propylnitro-samine-induced focal proliferative and neoplastic syrian hamster pancreatic lesions 共著

Virchows Arch.B.(Cell Pathol), 52, 479-488.

1985年

論文 Identification of a characteristic Cytosolic polypeptide of rat preneoplastic hepatocyte nodules an placental glutathione S-transferase 共著

Biochem.Bio Phys Res. Commun., 14, 98-103.

1985年

論文 Relative merits of immunohistochemical demonstrations of placental, A, B, and forms of glutathione S-transferase as markers of altered cell foci during liver carcinogenesis 共著

Carcinogene sis, 6, 1621-1626.

1985年

論文 Identification of heterogeneous and microheterogeneous subunits of glutathione S-transferase in rat liver cytosol 共著

Arch.Biophys.Biochem., 242, 104-111.

1985年

論文 Purification, induction, and distribution of placental glutathione transferase (GST-P): a new marker enzyme for preneoplastic cells in rat chemical hepatocarcinogenesis. 共著

Proc Natl Acad Sci USA, 82, 3964-3968.

1985年

論文 Changes in molecular forms of rat hepatic glutathione transferase during chemical hepatocarcinogenesis 共著

Cancer Res., 44, 2698-2703.

1984年

論文 Characterization of nuleolar antigens of normal, regenerating rat liver, and Novikoff ascites hepatoma cells following in vitro translation of polyadenylic acid containing messenger RNA 共著

Cancer Res., 43, 2143-2149.

1983年

論文 Purification of RNA associated and unassociated forms of α- glucan branching enzyme from rat liver 共著

J.Biochem., 91, 1129-1137.

1982年

論文 An activity staining method ofα-1,4-glucan branching enzyme by the cooperative action with glycogen phosphorylase immobilized within polyacrylamide gels 共著

Anal.Biochem., 108, 16-24.

1980年

論文 The high autoantibody activity of antibodies to rat skeletal muscle glycogen phosphorylase b produced in rabbits. 共著

Biochim. Biophys. Acta, 578, 520-525.

1979年

論文 A new glycogen phosphorylase present in the rat tissues containing the brain-type isozyme. 共著

FEBS Lett., 95, 239-242.

1978年

論文 Isozyme patterns of glycogen phosphoryl- ase in rat tissues and transplantable hepatomas 共著

Cancer Res., 36, 487-495.

1976年

論文 Substituent effect of ribonuclease T1- catalyzed transphosphorylation of para- substituted benzyl esters of guanosine-3′-phosphate. 共著

Chemistry Lett., 551-556.

1975年

論文 東京大学理学部生物科学 (1974) リボヌクレアーゼ触媒リン酸基転移反応およびそれらのモデル反応における置換基効果。 単著

東京大学出版会
(学位論文)

1974年

論文 Synthesis and reaction of a series of substituted benzyl esters of guanosine-3′-phosphate. 共著

Chemistry Lett., 1097-1100.

1972年

論文 Column chromatographic separation of a so-far unresolved sequence isomers UpCpGp and CpUpGp, and their optical properties. 共著

Anal. Biochem., 39, 263-268.

1971年

論文 Ion-exchange chromatography of a dinucleotide preparation from controlled alkalinehydrolysis of ribonucleic acids 共著

Biochem.J., 114, 271-277.

1969年

論文 Optical rotatory dispersion of five homo dinucleotides 共著

Biochem.J., 113, 843-851.

1969年

その他(資格、賞など)

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