研究業績
佐藤 公彦 (SATO KIMIHIKO) 教授
専門分野
有機化学
生化学
化学発がん
生命科学
略歴
東北大学理学部化学科卒業
東北大学大学院理学研究科修士課程終了
東京大学理系大学院博士課程修了
弘前大学医学部生化学第二講座助手
弘前大学医学部生化学第二講座助教授
弘前大学大学院保健学研究科教授
弘前大学名誉教授
秋田看護福祉大学教授
最終学位
理学博士（東京大学大学院)
所属学会
日本癌学会
日本分子腫瘍マーカー研究会（特別会員）
アメリカ癌学会
研究課題
がん細胞の発生機構の解明に関する研究
社会活動
大館市環境審議会委員
主な研究実績
| 区分 | 著書・学術論文等の題名 | 単著/ 共著 |
発行所・発表雑誌等又は 発表学会名 |
発行又は発表年月 |
|---|---|---|---|---|
| 論文 | Strong carcinogenic stress response induction of preneoplastic cells positive for GST-P in the rat liver: Physiological mechanism for initiation | 単著 |
Life Sciences, 200, 42-48. |
2018年 |
| 論文 | Nonclonal growth of preneoplastic cells positive for glutathione S-transferase P-form in the rat liver. | 共著 |
Cancer Sci., 103(8), 1445-1450. |
2012年 |
| 論文 | Bile duct-bound growth of precursor cells of preneoplastic foci inducible in the initiation stage of rat chemical hepatocarcinogenesis by 2-acetylamino- fluorene. | 共著 |
Jpn J. Clin. Oncol., 38, 604-610. |
2008年 |
| 論文 | Altered gene expression of transcriptional regulatory factors in tumor marker-positive cells during chemically induced hepatocarcinogenesis. | 共著 |
Toxicol Lett., 167(2), 106-13. |
2006年 |
| 論文 | Enzymatic detection of precursor cell populations of preneoplastic foci positive for (-glutamyltranspeptidase in rat liver. | 共著 |
Int. J. Cancer , 115(5), 711-716. |
2005年 |
| 論文 | Kinetic-controlled Hydrolysis of Leu-Val-Val-hemorphin-7 Catalyzed by Angiotensin-converting Enzyme from Rat Brain | 共著 |
Peptides, 24(7), 1075-1082. |
2003年 |
| 論文 | Anomalous elevation of glutathione S-transferase P-form (GST-P) in the elementary process of epigenetic initiation of chemical hepatocarcinogene is in rats. | 共著 |
Carcinogenesis, 23(7), 457- 462. |
2002年 |
| 論文 | Activation of mouse Pi-class gluta-thione S-transferase gene by Nrf2(NF-E2-related factor 2) and androgen. | 共著 |
Biochem. J., 364(Pt 2), 563-570. |
2002年 |
| 論文 | Nrf2 transactivator-independent GSTP1-1 expression in “GSTP1-1 positive” single cells inducible in female mouse liver by DEN: a preneoplastic character of possible initiated cells | 共著 |
Carcinogenesis, 23(3), 457-462. |
2002年 |
| 論文 | Lipid peroxidation end products-responded induction of a preneoplastic marker enzyme glutathione S-transferase P-form (GST-P) in rat liver on admistration via the portal vein. | 共著 |
Mutation Res., 483(1-2), 65-72. |
2001年 |
| 論文 | Increase intake water for prevention of cancer: an enzymological lesson? | 単著 |
Asian Pacific J Cancer Prevention, 2, 75-80. |
2001年 |
| 論文 | Oxidative stress promotes the development of transformation: involvement of a potent mutagenic lipid peroxidation product, acrolein. | 共著 |
Carcinogenesis, 22(6), 935-941. |
2001年 |
| 論文 | Cyclopentenone prostaglandins as potential inducers of phase II detoxification enzymes, 15-deoxy-delta(12,14)-prostaglandin J2-induced expression of glutathione S-transferases | 共著 |
J. Biol. Chem., 275, 11291-11299. |
2000年 |
| 論文 | A One-Hour ELISA for Quantitation of Acrolein and Hydroxynonenal-Modified proteins by Epitope-Bound Casein Method. | 共著 |
Anal Biochem., 270(2), 323-328. |
1999年 |
| 論文 | Quantitative differences in the active site hydrophobicity of five huma glutathione S-transferase isoenzymes: Water-soluble carcinogen selective properties of the neoplastic GSTP1-1 species. | 共著 |
Arch.Biochem. Biophys., 361, 271-276. |
1999年 |
| 論文 | Weak electrophile selective characteristics of the rat preneoplastic marker Enzyme glutathione S-transferase P-form, GST-P(7-7): A theory of linear free energy relationships for evaluation of the active site hydrophobicity of isoenzymes. | 単著 |
Garcinogenesis, 19(9), 1665-1671. |
1998年 |
| 論文 | Over-expression of glutathione S-transferase Yp isozyme and concomitantdown-regulation of Ya isozyme in renal Cell carcinoma of rats induced by ferric nitrilotriacetate | 共著 |
Carcinogenesis, 19(5), 897-903. |
1998年 |
| 論文 | An Nrf2/Small Maf heterodimer mediates the induction of PhaseⅡ detoxifying enzyme genes through antioxidant response elements | 共著 |
Biochem.Biophys.Res.Commun., 236, 313-322. |
1997年 |
| 論文 | Epitope mapping of a monoclonal antibodyto human glutathione transferase P1-1 the binding of which is inhibited by glutathione | 共著 |
Biochem.J., 321, 531-536. |
1997年 |
| 論文 | Lentinan enhance sensitivity of mouse colon 26 tumor to and decreases glutathione transferase expression | 共著 |
J pn.J.Cancer Res., 87, 1171-1178. |
1997年 |
| 論文 | Oxidative stress response in iron-Induced renal carcinogenesis: Acute nephrotoxicity mediates the enhanced expression of glutathione S-transferase Yp isozyme | 共著 |
Arch.Biochem.Biophys., 329, 39-46. |
1996年 |
| 論文 | The high non-enzymatic conjugation rates of some glutathione S-transferase(GST) substrates at high glutathione concentrations | 共著 |
Carcinogenesis, 16, 869-874. |
1995年 |
| 論文 | Effect of fish oil on the development of AOP-induced glutathione S-transferase placental form positive hipatocellular foci in make F344 rats | 共著 |
Nutrition and Cancer, 24, 187-195. |
1995年 |
| 論文 | Decreased exp ression of glutathione S-transferases and increased fatty change in peroxisomal enzye-negative foci induced by clofibrate in rat livers | 共著 |
Carcinogenesis, 16, 1609-1704. |
1995年 |
| 論文 | Lack of correlated expression between the glutathione S- transferase P-form and the oncogene products, c-Jun and c-Fos, in rat tissues and preneoplastic hepatic foci | 共著 |
Carcinogenesis, 16, 567-571. |
1995年 |
| 論文 | c-Jun expression in single cells and preneoplastic foci induced by diethylnitrosamine in B6C3F1 mice:comparison with the expression of pi-class glutathione S-transferase | 共著 |
Carcinogenesis, 15, 1853-1857. |
1994年 |
| 論文 | Loss of peroxisomal enzyme espression in preneoplastic and neoplastic lesios induced by poroxisome proliferators in rat livers | 共著 |
Carcinogenesis, 13, 265-269. |
1992年 |
| 論文 | Specific expression of glutathione S-transferase Pi forms in preneoplastic tissues: Their properties and functions | 共著 |
Thoku J.Exp.Med., 168, 97-103. |
1992年 |
| 論文 | Modulation of class Pi glutathione Transferase activity by sulfhydryl Group modification | 共著 |
Arch.Viochem. Viophys., 268, 178-182. |
1991年 |
| 論文 | Biochemical characteristics of a preneoplastic marker enzyme glutathione S-transferase P- form(7-7) | 共著 |
Arch.Biochem.Biophys., 285, 312-316. |
1991年 |
| 論文 | Age-related alterations of enzyme activities and subunits of gepatic glutathione S-transferases in make and femate Fischer-344 rats | 共著 |
Biochem. Bio Phys Acta, 1077, 325-331. |
1991年 |
| 論文 | Induction of glutathione S-transferase P-form in primary cultured rat liver Parenchymal cells by co-planar Polychlorinated biphenyl congeners | 共著 |
Biochem.J., 281, 539-543. |
1991年 |
| 論文 | A new class of rat glutathione S-transferase Yrs-Yrs inactivating reactive sulfate esters as metabokites of acrcinogenic arylmethanol | 共著 |
J.Biol.Chem., 265, 11973-11981. |
1990年 |
| 論文 | A cDNA sequence a class pi glutathione S-transferase of mouse | 共著 |
Nucleic Acids Res., 18, 4606. |
1990年 |
| 論文 | Role of cysteine residues in the Activity of rat glutathione transferase P(7-7) | 共著 |
Biochem. Biophys Res Commun, 1077, 325-331. |
1990年 |
| 論文 | Comparison of enzyme phonetypes in human Bladder tumors and experimentally induced hyperplastic and neoplastic lesions of the rat urinary bladder | 共著 |
Virchows Arch. V. Cell Pathol., 56, 307-316. |
1989年 |
| 論文 | Transient induction of single GST-P positive hepatocytes by DEN | 共著 |
Carcinogene sis, 10, 2107-2111. |
1989年 |
| 論文 | Stable phenotypic expression of glutathione S-transferase placental form and unstable phenotypic expression of γ-glutamyltransferase in rat liver preneoplastic and neoplastic lesions | 共著 |
Carcinogene sis, 9, 215-220. |
1988年 |
| 論文 | The subunit structure of a major glutathione S-transferase form, Mt,in rat testis | 共著 |
Eur.J.Bio chem., 176, 551-557. |
1988年 |
| 論文 | Single GST-P positive liver cells—putative initiated hipatocytes | 共著 |
Carcinogene sis, 8, 483-486. |
1987年 |
| 論文 | Purification of a new acidic glutathione S-transrerase,GST-Yn１Yn１,with a high leukotriene- C4 synthase activity from rat brain transferase isozymes | 共著 |
Eur.J.Bio chem., 170, 159-164. |
1987年 |
| 論文 | Immunohistochemically demonstrated increase in glutathione S-transferase species in propylnitro-samine-induced focal proliferative and neoplastic syrian hamster pancreatic lesions | 共著 |
Virchows Arch.B.(Cell Pathol), 52, 479-488. |
1985年 |
| 論文 | Identification of a characteristic Cytosolic polypeptide of rat preneoplastic hepatocyte nodules an placental glutathione S-transferase | 共著 |
Biochem.Bio Phys Res. Commun., 14, 98-103. |
1985年 |
| 論文 | Relative merits of immunohistochemical demonstrations of placental, A, B, and forms of glutathione S-transferase as markers of altered cell foci during liver carcinogenesis | 共著 |
Carcinogene sis, 6, 1621-1626. |
1985年 |
| 論文 | Identification of heterogeneous and microheterogeneous subunits of glutathione S-transferase in rat liver cytosol | 共著 |
Arch.Biophys.Biochem., 242, 104-111. |
1985年 |
| 論文 | Purification, induction, and distribution of placental glutathione transferase (GST-P): a new marker enzyme for preneoplastic cells in rat chemical hepatocarcinogenesis. | 共著 |
Proc Natl Acad Sci USA, 82, 3964-3968. |
1985年 |
| 論文 | Changes in molecular forms of rat hepatic glutathione transferase during chemical hepatocarcinogenesis | 共著 |
Cancer Res., 44, 2698-2703. |
1984年 |
| 論文 | Characterization of nuleolar antigens of normal, regenerating rat liver, and Novikoff ascites hepatoma cells following in vitro translation of polyadenylic acid containing messenger RNA | 共著 |
Cancer Res., 43, 2143-2149. |
1983年 |
| 論文 | Purification of RNA associated and unassociated forms of α- glucan branching enzyme from rat liver | 共著 |
J.Biochem., 91, 1129-1137. |
1982年 |
| 論文 | An activity staining method ofα-1,4-glucan branching enzyme by the cooperative action with glycogen phosphorylase immobilized within polyacrylamide gels | 共著 |
Anal.Biochem., 108, 16-24. |
1980年 |
| 論文 | The high autoantibody activity of antibodies to rat skeletal muscle glycogen phosphorylase b produced in rabbits. | 共著 |
Biochim. Biophys. Acta, 578, 520-525. |
1979年 |
| 論文 | A new glycogen phosphorylase present in the rat tissues containing the brain-type isozyme. | 共著 |
FEBS Lett., 95, 239-242. |
1978年 |
| 論文 | Isozyme patterns of glycogen phosphoryl- ase in rat tissues and transplantable hepatomas | 共著 |
Cancer Res., 36, 487-495. |
1976年 |
| 論文 | Substituent effect of ribonuclease T１- catalyzed transphosphorylation of para- substituted benzyl esters of guanosine-3′-phosphate. | 共著 |
Chemistry Lett., 551-556. |
1975年 |
| 論文 | 東京大学理学部生物科学 (1974) ﾘﾎﾞﾇｸﾚｱｰｾﾞ触媒ﾘﾝ酸基転移反応およびそれらのﾓﾃﾞﾙ反応における置換基効果。 | 単著 |
東京大学出版会 |
1974年 |
| 論文 | Synthesis and reaction of a series of substituted benzyl esters of guanosine-3′-phosphate. | 共著 |
Chemistry Lett., 1097-1100. |
1972年 |
| 論文 | Column chromatographic separation of a so-far unresolved sequence isomers UpCpGp and CpUpGp, and their optical properties. | 共著 |
Anal. Biochem., 39, 263-268. |
1971年 |
| 論文 | Ion-exchange chromatography of a dinucleotide preparation from controlled alkalinehydrolysis of ribonucleic acids | 共著 |
Biochem.J., 114, 271-277. |
1969年 |
| 論文 | Optical rotatory dispersion of five homo dinucleotides | 共著 |
Biochem.J., 113, 843-851. |
1969年 |
その他（資格、賞など）
放射線取扱い主任者一種免状